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Prolonged dopamine signalling in striatum signals proximity and value of distant rewards. Galvan A, et al. Influence of alcohol use and family history of alcoholism on neural response to alcohol cues in college drinkers. Increased impulsive reward-seeking and dopamine responsivity prior to drug use A recent series of adoption, twin, and longitudinal follow-up studies have supported a strikingly consistent conclusion: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity. Adolescent alcohol use is predicted by childhood temperament factors before age 5, with mediation through personality and peers.

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Le Foll B, Boileau I. For example, adolescents with high externalizing traits make risky choices, preferring high frequency rewards even when the losses are higher [ 23 - 25 ]. Dopamine release in ventral striatum of pathological gamblers losing money. With sustained drug use, both effects become exaggerated leading to a progressively increased preoccupation with drug taking and a progressively decreased interest in normal daily non-drug activities. Inadequate early social experience increases the incentive salience of reward-related cues in adulthood.

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